Barcelona suffered a first home defeat of the season when they lost 3-2 against Valencia after finishing with 10 men in La Liga on Saturday, leaving the door open for Madrid rivals Atletico and Real to move above them.
Second-half headers from Diego Godin and Raul Garcia gave holders Atletico Madrid a 2-0 win over Valencia and a place in the King's Cup quarter-finals by 3-1 on aggregate.
Cristiano Ronaldo's Champions League debut for Juventus lasted only 29 minutes as he was red-carded but the Italians began their Group H campaign impressively with a 2-0 victory at Valencia on Wednesday. Penalties either side of halftime by Miralem Pjanic sealed the points for the visitors as Valencia's return to European competition after a two-year absence fell flat.
Alvaro Negredo struck in stoppage-time as stuttering Valencia won 2-1 against his former club Sevilla on Sunday to earn coach Pako Ayesteran victory in his first home game in charge since succeeding Gary Neville.
Real Madrid's unbeaten start to the La Liga season came to an abrupt and surprising end as Real Mallorca claimed a stunning 1-0 victory at a rocking Son Moix on Saturday to climb out of the relegation zone.
Bruno Fernandes and Edinson Cavani scored twice each as Manchester United took a giant step towards the Europa League final with a 6-2 drubbing of AS Roma in their semi-final first leg at Old Trafford on Thursday.
Arsenal's Pierre-Emerick Aubameyang struck a vital late goal to seal a 3-1 win over Valencia on Thursday and give his side breathing space for the second leg of their Europa League semi-final in Spain next week.
A Neymar double and a clinical finish from Luis Suarez handed Barcelona a comfortable 3-0 victory over BATE Borisov that put them on the verge of qualifying for the last 16 of the Champions League for the 12th consecutive season.
An Aaron Ramsey strike and a Kalidou Koulibaly own goal gave Arsenal a 2-0 victory over Napoli in the first leg of their Europa League quarter-final, while Chelsea beat a stubborn Slavia Prague 1-0.
A summary of Wednesday's matches in the UEFA Champions League.
Vietto slotted the ball home with seven minutes to go after Karim Benzema had given visitors Real the lead early on.
IMAGES from the Champions League matches played on Tuesday
Lionel Messi dragged Barcelona back from two goals down by scoring twice to snatch a 2-2 draw at home to Valencia in a thrilling encounter.
Atletico Madrid got their La Liga campaign up and running in less than convincing fashion when Antoine Griezmann's deflected free kick secured an edgy 1-0 win at home to promoted Las Palmas on Saturday.
Images from the Champions League matches played across Europe on Tuesday
Football news from Ligue 1, Bundesliga and La liga.
A summary of the results of the major European football league matches on the weekend.
Chelsea struck the woodwork twice but could not find a breakthrough in an entertaining 0-0 Champions League draw at Dynamo Kiev on Tuesday that left everything to play for in Group G.
